The Journal of biological chemistry . oils extracted frominternal organs such as the liver its presence is well priori it does not seem admissible that the vitamine is dis-tributed in these tissues because of its indispensable role in thesevarious organs. It seemed far more logical to assume especiallyin view of its association with the fats that excess of the vitamineis stored as such in various oi-gans for future use. We have put this matter to experimental test using rat liversas the material for investigation. So far as we know no dataon the fat-soluble vitamine content of rat
The Journal of biological chemistry . oils extracted frominternal organs such as the liver its presence is well priori it does not seem admissible that the vitamine is dis-tributed in these tissues because of its indispensable role in thesevarious organs. It seemed far more logical to assume especiallyin view of its association with the fats that excess of the vitamineis stored as such in various oi-gans for future use. We have put this matter to experimental test using rat liversas the material for investigation. So far as we know no dataon the fat-soluble vitamine content of rat livers are available, Steenbock, Sell, and Nelson 339 but we assumed that ordinarily their content of this dietary es-sential is comparable with that of pigs liver and this when^fedat a level of 1 per cent of our ration had been found to be on theborder-line of furnishing enough of this vitamine. If storage ofthe vitamine takes place we would naturally expect more of thevitamine to be found in the livers of normal rats than in those. Chart V. Shows the difference in growth of young rats on rations de-riving their fat-soluble vitamine from rat livers obtained from rats rearedon rations low in fat-soluble vitamine as compared with those reared inrations of normal fat-soluble vitamine content. The rats in Group 1390receiving the former reached a maximum weight of 115 to 172 gm. then failedrapidly and died within a period of 10 weeks after the experiment wasstarted. Rats 4432, 4433, and 4434 all contracted ophthalmia before way of contrast, rats in Group 1388 reached a maximum weight of 188to 297 gm., continued growth at a normal rate to the end with no signs ofophthalmia, and with one exception, Rat 4423, lived till the termination ofthe experiment. Apparently 1 per cent of normal liver does not, however,provide an excess of fat-soluble vitamine because Rat 4423 in the 14thweek on the ration contracted ophthalmia and respiratory infections. 340 Fat-Soluble Vitamine. XI G
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