Practical pathology; a manual for students and practitioners . and nuclei not so distinctly seen as Collecting tubules, little altered. .]/. Malpighian body slightly more prominent than usual, appar-ently because of numerous and more distinct nuclei. the sections of the convoluted tubules present a greater surface thanin the normal organ. The lumen is very irregular, and often appearsto be little more than a star-shaped fissure. The epithelial cells-areso swollen that the diameter of each cell is increased : its outline isirregular but very well defmed. ( X 300).—The epithelial ce


Practical pathology; a manual for students and practitioners . and nuclei not so distinctly seen as Collecting tubules, little altered. .]/. Malpighian body slightly more prominent than usual, appar-ently because of numerous and more distinct nuclei. the sections of the convoluted tubules present a greater surface thanin the normal organ. The lumen is very irregular, and often appearsto be little more than a star-shaped fissure. The epithelial cells-areso swollen that the diameter of each cell is increased : its outline isirregular but very well defmed. ( X 300).—The epithelial cells are greatly enlarged. They areangular, and so project into the tubule that the lumen may be almostobliterated. The outlining of the cells is distinct, the protoplasm 390 THE KIDNEY is much more granular than in the normal condition, and the nucleusis obscured, though in a few cases it takes on the nuclear stain verydeeply, and may thus become more prominent. Treat a section withacetic acid (§ 189) or caustic potash (|^ 190); the cloudiness disappears,. Fig. 109.—Cloudy swelling of the kidney, where death has takenplace at a very early stage of the process. Stained with alum hremateinand van Giesons stain. ( x 500.) a. Swollen columnar epithelial cells of a convoluted tubule. Out- lines somewhat obscured; nuclei not very distinct ; proto-plasm coarsely granular. b. Swollen epithelial cells, with apices projecting into the lumen of the tubule, giving rise to the radiate or stellate fissures verycharacteristic of this condition. c. Coarsely granular protoplasm, breaking down. d. Lumen of intertubular capillary blood vessel. e. Basement membrane of capillary vessel and delicate connective tissue fibrils, hyaline, and much Upper part of collecting tubule—intermediate—with hyahnecast lying in lumen. and, with the exception of the change in size and shape, the epitheliumregains its normal appearance. If the change is of some standing—several days—a few


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