. The Alumni journal. College of Pharmacy of the City of New York; Pharmacology. PUBLISHED BY THE ALUMNI ASSOCIATION OF THE COLLEGE OF PHARMACY OF THE CITY OF NEW YORK 11 ^ LIBRAR NEW YOK botanio QARUEN Vol. 111. New York, May, 1896. No. 5. ASEPTIC CATGUT. By Charles Rice, Ph. D. There is much diversity of opinion among surgeons regarding the most ef- ficient way of rendering catgut ligatures absolutely sterile. Some still prefer the old-fashioned carbolized gut, prepared by macerating or digesting the raw gut with a 5 to 10 per cent, solution of carbolic acid, or chromicized gut, made by ma-
. The Alumni journal. College of Pharmacy of the City of New York; Pharmacology. PUBLISHED BY THE ALUMNI ASSOCIATION OF THE COLLEGE OF PHARMACY OF THE CITY OF NEW YORK 11 ^ LIBRAR NEW YOK botanio QARUEN Vol. 111. New York, May, 1896. No. 5. ASEPTIC CATGUT. By Charles Rice, Ph. D. There is much diversity of opinion among surgeons regarding the most ef- ficient way of rendering catgut ligatures absolutely sterile. Some still prefer the old-fashioned carbolized gut, prepared by macerating or digesting the raw gut with a 5 to 10 per cent, solution of carbolic acid, or chromicized gut, made by ma- cerating the raw gut during forty-eight hours in a solution of 50 Gm. of carbolic acid and Gm. of chromic acid in i litre of water, then removing and drying the gut, and transfering it to carbolized oil (i in 5.) Others, and probably the majority of surgeons prefer catgut which has been sterilized by certain liquids with the aid of heat. The liquid most gener- ally used for this purpose is alcohol. In using alcohol for sterilizing catgut, it has been found that the more water the alcohol contains, the lower must be the temperature of digestion; otherwise the gut will soften or become rotten. If ab- solute alcohol be used, the gut may be enclosed with it in hermetically sealed vessels, preferably glass tubes closed in the flame, and subjected to a heat, under pressure, up to 230° F. and more, with- out the least injury to its strength. If it were subjected to such treatment while in contact with hydrous alcohol, it would become weak and altogether worthless. Yet, the ordinary 94% alcohol may be used if the temperature is not carried be- yond the boiling point of the liquid at the ordinary atmospheric pressure, that is, if the alcohol is boiled in an open vessel. And in this case it has been found that the boiling should not be con- tinued materially beyond one hour. At one time, sublimated gut was recommen- ed and in use. This was prepared by adding a certain proportion, u
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