. Currents in biochemical research, 1956; twenty-seven essays charting the present course of biochemical research and considering the intimate relationship of biochemistry to medicine, physiology, and biology. Biochemistry -- Research. PROTEIN STRUCTURE would seem to be highly improbable" (5, ). The identi- fication of an interhelical packing peak does not define rigorous interhelical parallelism. The experimental scattering curves simply indicate that there are certainly considerable regions of interchain order in the molecule. X-ray crystal structure studies of hemoglobin have led
. Currents in biochemical research, 1956; twenty-seven essays charting the present course of biochemical research and considering the intimate relationship of biochemistry to medicine, physiology, and biology. Biochemistry -- Research. PROTEIN STRUCTURE would seem to be highly improbable" (5, ). The identi- fication of an interhelical packing peak does not define rigorous interhelical parallelism. The experimental scattering curves simply indicate that there are certainly considerable regions of interchain order in the molecule. X-ray crystal structure studies of hemoglobin have led to this same general conclusion. The vector structure for hemo- globin suggests a molecular structure which may be represented. Fig. 7. Horse methemoglobin. Idealized representation of mol- ecule in a plane projection. The circles correspond to the end-on view of rodlike regions of high electron density in close-packed array. W. L. Bragg, E. R. Howells, and M. F. Perutz, Acta Cryst., 5, 136 (1952). in cross section as shown in Figure 7. In this idealized model the circles represent the end-on projection of peptide chains stacked in close-packed array with each chain coiled in some regular configuration. The molecular length parallel to the a axis and normal to this section is approximately 62 A. The molecule is bisected by a twofold symmetry axis normal to a. An individual single coiled chain could not therefore be longer than «/2, that is 31 A. In considering agreement between this model and the experimental data both Bragg, Howells, and Perutz (16) and Crick (30) have shown that the model is over- simplified. 409. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Green, David Ezra, 1910-. New York, Interscience Publishers
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