. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. 404 Colchicine chemical reactivity. After studying these simple spindle poisons, some other substances acting like colchicine, or those with complex mole- cular structure will be examined briefly. The properties of colchicine will then be compared to those of other poisons. : Colchicine derivatives. These have been studied from three main points of view: their toxicity, their antimitotic activity, C O u o o £ _o c "" .0 '** u — o O - o ji — «o. Colchicine -6 .5 _4 .3 .2 .1 _0 Solubility(l
. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. 404 Colchicine chemical reactivity. After studying these simple spindle poisons, some other substances acting like colchicine, or those with complex mole- cular structure will be examined briefly. The properties of colchicine will then be compared to those of other poisons. : Colchicine derivatives. These have been studied from three main points of view: their toxicity, their antimitotic activity, C O u o o £ _o c "" .0 '** u — o O - o ji — «o. Colchicine -6 .5 _4 .3 .2 .1 _0 Solubility(log. mol. fraction) Fig. —Relation between c-mitotic activity in the Allium test and solubility in water. Each dot or triangle corresponds to a different substance. The singular behavior of colchicine is evident. (After Ostergren, 1951 '") and their inhibition of tumor ^ The spindle poisoning will mainly interest us here, and it should be made clear that this is not necessarily paralleled by other properties of these molecules. For in- stance, it has long been known that colchiceine (II) is less toxic, and also a weaker mitotic poison than colchicine. But desacetylcolchiceine, trimethylcolcliicinic acid (III) ,'"'-^ does not interfere ai all with cell division in animals, while it may, like colchicine, kill frogs by central nervous paralysis. The opposite is also true; and results to be discussed further point to the possibility of synthesizing derivatives with lower toxicity and greater mitotic-poisoning effects than Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Eigsti, O. J. (Orie Jacob), 1908-; Dustin, Pierre. Ames, Iowa State College Press
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