. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. •ec. Figure 3. Changes in the ERG of an isolated eye induced by serotonin. The ERG waveform recorded at CT 20 with a characteristic B-C wave is shown in A. At CT the ERG had changed to the subjective day waveform, lacking the B-C wave. Thirteen min after the addition of10~6 M serotonin, the ERG shown in C with a prominent B-C wave was recorded. The B-C wave progressively increased until the maximum response in D was observed at 43 min after the addition of serotonin. At that time the latency of the A wave had decreased a
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. •ec. Figure 3. Changes in the ERG of an isolated eye induced by serotonin. The ERG waveform recorded at CT 20 with a characteristic B-C wave is shown in A. At CT the ERG had changed to the subjective day waveform, lacking the B-C wave. Thirteen min after the addition of10~6 M serotonin, the ERG shown in C with a prominent B-C wave was recorded. The B-C wave progressively increased until the maximum response in D was observed at 43 min after the addition of serotonin. At that time the latency of the A wave had decreased about 100 ms, and the A wave amplitude had increased 140%. Vertical scale is 20 »V per division. The black bar on the time scale marks the 1-s light (.8 nW/cnr) pulse. rate is maximal. Thus, the maximal B-C wave occurs dur- ing minimal CAP rate in an antiphase relationship. The B-C wave decreases in size sharply during the increase in CAP rate at subjective dawn, suggesting that a high CAP rate might suppress the B-C wave. However, the causal relationship between these events has not been deter- mined. Isolated eyes, and eyes attached to the cerebral ganglion, exhibited similar ERG rhythms suggesting that the B-C wave pacemaker resides within the eye and that it is likely to be the CAP circadian pacemaker. The in- duction of the B-C wave by serotonin is an intriguing observation that will be addressed later in this Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Marine Biological Laboratory (Woods Hole, Mass. ); Marine Biological Laboratory (Woods Hole, Mass. ). Annual report 1907/08-1952; Lillie, Frank Rattray, 1870-1947; Moore, Carl Richard, 1892-; Redfield, Alfred Clarence, 1890-1983. Woods Hole, Mass. : Marine Biological Laboratory
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