. A practical study of malaria. ith the life historyof the malarial parasites (Fig. 49). The paroxysm is not immediately associated with the gradualvegetative growth of the parasite within the corpuscle, but,occurring more or less abruptly as it does, is simultaneous withsporulation and the sudden discharge into the blood stream ofa new generation of parasites. In what manner does thisprocess produce so peculiar a phenomenon as the malarialparoxysm? Golgi87 was of the opinion that it was dependent9 13° THE STUDY OF MALARIA upon the entrance into fresh red cells of the young generationof parasi
. A practical study of malaria. ith the life historyof the malarial parasites (Fig. 49). The paroxysm is not immediately associated with the gradualvegetative growth of the parasite within the corpuscle, but,occurring more or less abruptly as it does, is simultaneous withsporulation and the sudden discharge into the blood stream ofa new generation of parasites. In what manner does thisprocess produce so peculiar a phenomenon as the malarialparoxysm? Golgi87 was of the opinion that it was dependent9 13° THE STUDY OF MALARIA upon the entrance into fresh red cells of the young generationof parasites. This, however, is shown to be erroneous by thefact that a properly timed and adequate dose of quinine givenbefore the chill is expected does not prevent the access thoughit does destroy the young parasites, preventing their invasionof the cells. The true explanation of the origin of the paroxysm isthrough the agency of a toxin liberated by the sporulative existence of a toxin, the product of the malarial parasite,. cm QqqU o © Fig. 49.—The relation between the stages of the parasite and the paroxysm. is almost universally assumed by students of malaria. Thegrounds for this assumption may be recounted as follows: 1. An analogy with other infectious diseases. 2. Immunity; this immunity is not absolute, but that a rela-tive immunity to malaria exists there is no room for doubt. 3. The formation of an antitoxin; Fords140 experimentsbeing conclusive as to the existence of such. 4. Degenerative changes in the kidneys, liver, spleen, andother organs not otherwise explainable. 5. Blood changes, as anemia out of proportion to the num- ETIOLOGY 131 ber of parasites, and brassy degeneration, stippling, and poly-chromatophilia of the red cells. 6. Increased toxicity of the urine and sweat. 7. The existence of coma in malaria without parasites orpigment in the brain. 8. The fever and its relation to parasitic sporulation. 9. Experimental proof. The negative results of Guald
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectmalaria, bookyear1909
