Archives of internal medicine . Tbresbolcj _j0^ death i ^i-. Thresboid Of )^^^^^h»>^l observation _ A Fig. 7.—Anergy (antianaphylaxis). 414 THE ARCHIVES OF INTERNAL MEDICINE M £ C. E. VON PIRQUET 415 amount of horse-serum is relatively larger than the amount of antibody,and after the union has taken place, no free antibody is left. After aperiod of four days a new formation of antibody begins. The antibodydestroys the remainder of the horse-serum, and the result is again atoxic action, an accelerated serum disease. I have described thesecases of a combined early and accelerated reactio


Archives of internal medicine . Tbresbolcj _j0^ death i ^i-. Thresboid Of )^^^^^h»>^l observation _ A Fig. 7.—Anergy (antianaphylaxis). 414 THE ARCHIVES OF INTERNAL MEDICINE M £ C. E. VON PIRQUET 415 amount of horse-serum is relatively larger than the amount of antibody,and after the union has taken place, no free antibody is left. After aperiod of four days a new formation of antibody begins. The antibodydestroys the remainder of the horse-serum, and the result is again atoxic action, an accelerated serum disease. I have described thesecases of a combined early and accelerated reaction in the chapter onserum disease in man. During the time the antibody is lacking a repeti-tion of the horse-serum injection has no immediate effect, because thehorse-serum finds no antibody to unite it. This is shown in Figure 7,which shows an experiment on a rabbit several weeks after the first injec-tion of horse-serum. It contains antibody. A second injection (a) isperformed. The horse-serum injected unites immediately with the exist- .Second vaccination4- aftef lon^ InteYval


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