. Calcified tissues; proceedings. Bone; Collagen; Calcification. Absorption of Calcium in Man: Effect of Disease, Hormones and Vitamin D 199. Typical curves for the first four hours of observation are presented in Fig. 1. There are two separate studies of the same individual, a normal 21 year old male, plotted on the graph; the studies were performed approximately six weeks apart. Excellent reproducibility of observations was achieved. In all patients there was a lag period of 10 to 30 minutes after ingestion before any discernible radioactivity above background could be measured in the forear


. Calcified tissues; proceedings. Bone; Collagen; Calcification. Absorption of Calcium in Man: Effect of Disease, Hormones and Vitamin D 199. Typical curves for the first four hours of observation are presented in Fig. 1. There are two separate studies of the same individual, a normal 21 year old male, plotted on the graph; the studies were performed approximately six weeks apart. Excellent reproducibility of observations was achieved. In all patients there was a lag period of 10 to 30 minutes after ingestion before any discernible radioactivity above background could be measured in the forearm. Thereafter, there was a relati- vely rapid increase, persisting for about two hours in most subjects. From this point on, the increase was more gradual, levelling oft' in about for to six hours. The maximum activity in the forearm was usually present at between 24 and 36 hours after administration of the dose and thereafter, fell gradually. Attempts have been made to cor- relate values for apparent absorption obtained from direct stool measurements with various numerical parameters of the arm count curves. Numerical ana- lysis of the plot indicated that four numbers could be readily calculated to describe the semi-logarithmic plot of data: "kj", representing the initial slope; "ko", representing the slope of the last portion; "a/', representing the intercept of the first portion; and "ao", representing the intercept of the last portion. Statistical correlations were made between each of these four parameters and the net absorption calculated from stool recoveries. Absorption was directly related to "a^", the inter- cept value for the asymptotic horizontal portion of the curve and to "ki". The correlations obtained, however, were of the order of with a probability of less than that these were due to chance. Because of the low correlation values for individual observations, it was concluded that while absolute ab


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