Nervous and mental diseases . on. The embryonic vulnerability of this portion of thecord may serve to locate the lesions in these instances in the loAver levelsthrough the intermediary of the vascular supply and the action of toxicfactors. Morbid Anatomy.—The morbid anatomy of these family ataxiasvaries as the case corresponds to the spinal or the cerebellar type. Thecases that conform strictly to Friedreichs syndrome show a posterolateralsclerosis analogous in distribution to that of progressive spastic is a decided sclerosis of the columns of Goll and Burdach, withshrinking of t
Nervous and mental diseases . on. The embryonic vulnerability of this portion of thecord may serve to locate the lesions in these instances in the loAver levelsthrough the intermediary of the vascular supply and the action of toxicfactors. Morbid Anatomy.—The morbid anatomy of these family ataxiasvaries as the case corresponds to the spinal or the cerebellar type. Thecases that conform strictly to Friedreichs syndrome show a posterolateralsclerosis analogous in distribution to that of progressive spastic is a decided sclerosis of the columns of Goll and Burdach, withshrinking of the cord in this region throughout its entire length. Thereis sclerosis of the crossed pyramidal tract, of Goivers tract, of the directcerebellar tract, of Lissauers tract, and frequently atrophy of the cells ofClarkes column. The posterior horn and its cells are shrunken and inrare cases the anterior cornual cells are degenerated. Marie insists thatthe changes in the pyramidal tract are confined to the fibers related to the. Fig. 200.—Family tree of hereditary ataxia, reported by Dr. Sanger Brown. Explanation ofdiagram: Shaded inclosures indicate hereditary ataxia. Squares indicate males ; circles females. Thenumbers to the left refer to the cases in Browns paper ; the first number to the right, the age at deathor the present age. f indicates deceased. The last number indicates the age at onset. direct cerebellar tracts and Gowers tracts, and do not directly affect theupper motor neurons. The portions of the cord that last develop arethus affected by the retrogressive changes of the malady. As a rule,the cord is undersized and may present only two-thirds of its usualthickness. In a few cases, notably that of Menzel, the medulla andcerebellum were also reduced in size and degeneration has been tracedinto the cerebrum. The posterior roots and ganglia are usually normal. DISEASES OF THE WHITE MATTER OF THE CORD. 457 Rennie,1 however, found degeneration of posterior root-fibers
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