. Endocrinology. ntally these responses can be shown to be constant. It was with the intention of establishing some definitemethod of determining the value of the various ovarian prepara-tions that this investigation was undertaken. I wish to thank the various manufacturers of these prepara-tions, who so kindly donated the material for the experiments,and expressed their interest in the work and their desire to co-operate, namely, Parke, Davis & Co., Ilynson, Westcott & Dunn-ing, The Wilson Laboratories, and Burroughs, Wellcome & the Hynson, Westcott & Dunning preparations, we used the G
. Endocrinology. ntally these responses can be shown to be constant. It was with the intention of establishing some definitemethod of determining the value of the various ovarian prepara-tions that this investigation was undertaken. I wish to thank the various manufacturers of these prepara-tions, who so kindly donated the material for the experiments,and expressed their interest in the work and their desire to co-operate, namely, Parke, Davis & Co., Ilynson, Westcott & Dunn-ing, The Wilson Laboratories, and Burroughs, Wellcome & the Hynson, Westcott & Dunning preparations, we used the GEIST AND HARRIS 43 Corpus Luteum, the Ovarian Substance and the Ovarian the Parke-Davis preparations, the Corpus Luteum and theOvarian Substance with corpus hiteuni and without corpusluteum was used. Of the Wilson preparations, the CorpusLuteum was used. We did not complete the experiments withthe Burroughs-Wellcome preparations, as we found that feed-ing experiments were too njections of Wilson It is a well established fact that after castration a definite ~atrophy of the uterus takes place, and it was with the idea ofusing this phenomenon as an indicator that the experiments wereundertaken. We attempted to determine, if by the adminis-tration of these various preparations by intravenous injectionsthe atrophy could be prevented, minimized, or, if possible,hypertrophy could be obtained. At the same time, the breastswere also observed as well as the thyroid, hypophysis and adre-nals, to determine if the administration of these preparations hada definite effect on any of them. Controls were made by subject-ing animals to the same operative procedures, but withoutadministering the drugs. 44 VALUE OF OVARIAN EXTRACTS In the beginning we used 1 ce. of the substance for dailyinjection, but as the animals died after four or five injections,it was decided to increase the time interval between injections,so that 1 cc. was given every third day, beginning from five
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