Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . ereby bringing out the polar bodies. The organismis Gram-negative, and c^uite difficult to stain in sections. Pathogenesis.—Nicolle was the first to inoculate the monkey success-fully; the ordinary laboratory animals are immune. The lesion pro-duced in man is rarely extragenital. Ullman has been able to collect64 extragenital chancroids. It develops as a red point advancing toa papule, and later pustule, which ruptures, exposing a deep, crater-likeulcer the edges of which are often un
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . ereby bringing out the polar bodies. The organismis Gram-negative, and c^uite difficult to stain in sections. Pathogenesis.—Nicolle was the first to inoculate the monkey success-fully; the ordinary laboratory animals are immune. The lesion pro-duced in man is rarely extragenital. Ullman has been able to collect64 extragenital chancroids. It develops as a red point advancing toa papule, and later pustule, which ruptures, exposing a deep, crater-likeulcer the edges of which are often undermined and the discharge abun-dant. The ulcers sometimes take on phagedenic action and producewide-spread destruction. The lymph-nodes, anatomically nearest thelesion, enlarge and may suppurate (chancroidal bubo). In some casesthere is an intense, often polymicrobic, mixed infection with other organ-isms, usually of the pyogenic group. ^ See works referred to in foot-note, p. Si. The most important referencesto this organisiri can be obtained from paper by Davis, Jour. Med. Research,June, 1903, Bacillus ov Soft Chancre, HACTKHIA AS CAUSES (»!• DISEASE. »33
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