Transactions of the American Association of Obstetricians and Gynecologists for the year ... . ollowed by embarrassedrespiration and light anesthesia. The injections were made slowly into the ear vein. If givenrapidly, respiration would suddenly become shorter and graduallycease. Meltzer and Auer in a series of experiments demon-28 366 RALEIGH R. HUGGINS. strated that the conductivity of nerve trunks can be interruptedby the local application of magnesia solution, and that a more orless complete block for afferent and efferent, for normal or artifi-cial impulses can be established. The effect


Transactions of the American Association of Obstetricians and Gynecologists for the year ... . ollowed by embarrassedrespiration and light anesthesia. The injections were made slowly into the ear vein. If givenrapidly, respiration would suddenly become shorter and graduallycease. Meltzer and Auer in a series of experiments demon-28 366 RALEIGH R. HUGGINS. strated that the conductivity of nerve trunks can be interruptedby the local application of magnesia solution, and that a more orless complete block for afferent and efferent, for normal or artifi-cial impulses can be established. The effect of intravenous injection of magnesia sulphate uponthe alimentary canal was of considerable interest. It is generallyconsidered by those who are interested in the special study ofphysiological action of drugs that the saline purgatives producetheir effects in several ways: first, by preventing the absorp-tion of fluid from the alimentary canal, thereby retaining liquidin the tube; second, if given in proper concentration theycause a pouring out of fluid into the intestine, thereby adding to. Case 4. the amount which has been swallowed; third, it is supposedthat they stimulate peristalsis and so hurry the contents of thebowel toward the rectum. These views have recently been placed in doubt as to theircorrectness by investigations carried out by MacCallum, whoconfirms the earlier studies of Aubert to the effect that thesepurgatives act indirectly upon the intestinal wall if they are givenintravenously. On the other hand, Meltzer and Auer have deniedthe accuracy of these observations and assert that the intraven-ous injection of sulphate of sodium fails to produce purgation,but rather tends to constipation. Some of the difference inresults may be due to the character of the animal which wasemployed for experiment. It is well known that dogs are notpurged with elaterium, which is one of the most active waterypurges when given to human beings that we have. MAGNESIA SULPHATE IN BACTE


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