. The endocrine organs; an introduction to the study of internal secretion . ffected, dullness and apathy being prominent symptoms. Manynerve-cells, especially those of the cerebral cortex, exhibit a shrunkenappearance and present a strong contrast with those of the normal myxcedematous condition of the integument was described in monkeysby Horsley, Murray, and Edwards, but others (H. Munk, Kishi, Vincentand Jolly, Halpenny and Gunn) have not seen this. Similar symptoms are observed in cases of spontaneous atrophy, ordegeneration of the gland in children (fig. 18, A). There is arrest


. The endocrine organs; an introduction to the study of internal secretion . ffected, dullness and apathy being prominent symptoms. Manynerve-cells, especially those of the cerebral cortex, exhibit a shrunkenappearance and present a strong contrast with those of the normal myxcedematous condition of the integument was described in monkeysby Horsley, Murray, and Edwards, but others (H. Munk, Kishi, Vincentand Jolly, Halpenny and Gunn) have not seen this. Similar symptoms are observed in cases of spontaneous atrophy, ordegeneration of the gland in children (fig. 18, A). There is arrest of growth,especially of the skeleton, the cartilage bones long remaining incompletelyossified ; development of the generative organs is much delayed ; the integu-ment is swollen; the surface of the skin is dry; the hair tends to fall outand becomes thin ; the face is pale and puffy; the abdomen swollen; thenose depressed; the hands and feet are podgy. The fontanelles of the skull 29 30 The Endocrine Organs remain open. The muscles are limp and weak. Deaf-mutism is


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