Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . em-bryonal cartilage; in somecases they are multiple. Sar-coma originates in the peri-osteum or in the interior ofthe bone; any type of cellmay be present; giant-cellsarcomata frequently in-volve the maxillae and arethe least malignant. Occa-sionally sarcoma of bones iscongenital; tumors of thistype may begin in the me-dulla and cause extensiveosseous resorption terminat-ing in fracture without mani-festing any external evidences of their presence; they sometimesfollow injury. An impo
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . em-bryonal cartilage; in somecases they are multiple. Sar-coma originates in the peri-osteum or in the interior ofthe bone; any type of cellmay be present; giant-cellsarcomata frequently in-volve the maxillae and arethe least malignant. Occa-sionally sarcoma of bones iscongenital; tumors of thistype may begin in the me-dulla and cause extensiveosseous resorption terminat-ing in fracture without mani-festing any external evidences of their presence; they sometimesfollow injury. An important but rather infrequent tumor of boneis one arising in the marrow, apparently belonging with the sarco-mata, and known as the myeloma^ ; the condition is also calledmyelomatosis and Kahlers disease. The affection during life is oftendiagnosed osteomalacia. In one type of the morbid process the bonealone is involved, and in another metastases to the lymph-nodes andother structures occur. When the bodies of the vertebrae are involved, results. The cells composing the tumor are round or poh^he-. FiG. 404.—Sarcoma, Mixed-cell with Calcification ofPart of the Intercellular Matrix; Osteosarcoma. A. Calcified area in osteoid matrix. B. Osteoid tissue wliich, insome areas, gives rise to an alveolar arrangement. C- Osteo-blastic cell. 1 Revue de Chir., April 10, 1904, p. 5S9. ^ Annals of Surgery, June, 1903, p. 834. ^ Vignard and Gallavardin, Revue de Chir., Jan. 10, 1903. Weber, and Macleod, Amer. Jour, of Med. Sci., Oct., 1903. Lindemann, f. klin. Med., 1904, Bd. 81. Meltzer, Med. Record, June 18, 1904, Jellinek, Virchows Arch., 1904, Bd. 177, p. 96. BONES AND JOINTS. 825 dral, and resemble the ])lasma cell (p. ,^). Usually the growth de-velops primarily in the marrow of the vertebra;, hbs, and sternum, buteventuallv affects the marrow of all the bones. The affection is alsocharacterized by the ])resence in the urine of a peculiar protei
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