The British journal of dermatology . eeting effect). Examined with the ultra-microscope we find at firstan increase in the number of the particles (Fig. 2), then a gradualdiminution with a marked decrease in the size of the particles(Fig. 3), till finally the particles are reduced below the normal(Fig. 4) as the result of the continued dispersion. Sometimes, insteadof the giant particles and clumps becoming broken up and dispersed,they remain and cause the serum to give a positive or anti-com-plementary reaction (Fig. 5). As these are practically the only THE RATIONALE OF THE WASSEUMANX REACTI


The British journal of dermatology . eeting effect). Examined with the ultra-microscope we find at firstan increase in the number of the particles (Fig. 2), then a gradualdiminution with a marked decrease in the size of the particles(Fig. 3), till finally the particles are reduced below the normal(Fig. 4) as the result of the continued dispersion. Sometimes, insteadof the giant particles and clumps becoming broken up and dispersed,they remain and cause the serum to give a positive or anti-com-plementary reaction (Fig. 5). As these are practically the only THE RATIONALE OF THE WASSEUMANX REACTION. 57 ])avticles remaining- we come to tlie point tliat it is certain particleswhich are most concerned in the Snch a serum immediatelygives a negative reaction on the administration of a non-metal(intramine, di-ortho-di-amino-tliio-benzene) without the ultra-micro-scopic picture being changed. A negative reaction produced by toomany injections of a metal will sometimes become converted into a Antigen-f- eompLemenb•f-eerum. CompLement+? ser-um. AntLgen. + compiement •+ serurnCircle 1.—Ordinary complement fixation.


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Keywords: ., bookcentury1800, bookdecade1880, booksubjectsyphilis, bookyear188