General physiology; an outline of the science of life . being coloured blue by theiodine. Later it was recognised as a proteid-like body, for itcontains nitrogen and gives certain proteid reactions; hence, forthe present it is classed in the comprehensive group of behaviour with the aniline colour, methyl violet, is verycharacteristic; with it it takes on a beautiful ruby-red colour,while healthy tissues are coloured blue. By its character as analbuminoid, amyloid substance points plainly to its origin. It canbe derived only from the proteids of the cell, and, although thusfar
General physiology; an outline of the science of life . being coloured blue by theiodine. Later it was recognised as a proteid-like body, for itcontains nitrogen and gives certain proteid reactions; hence, forthe present it is classed in the comprehensive group of behaviour with the aniline colour, methyl violet, is verycharacteristic; with it it takes on a beautiful ruby-red colour,while healthy tissues are coloured blue. By its character as analbuminoid, amyloid substance points plainly to its origin. It canbe derived only from the proteids of the cell, and, although thusfar nothing is known in detail concerning its origin, it may safelybe considered as a metamorphosed proteid, which is excreted tothe outside by the cell and stored up. It never seems to be storedwithin the cell itself, it is always found rather in the connectivesubstances cementing the cells, especially in the walls of the smallblood-vessels (Fig. 148). But, in proportion as the cells secreteit, they die, whether as the result of perverse metabolism, the. THE GENERAL CONDITIONS OF LIFE 335 product of which is the amyloid substance, or because passivelythey are torn apart, pressed upon, asphyxiated and killed by thesubstance accumulating in masses. Amyloid metamorphosis is asecondary phenomenon of disease, appearing especially in connectionwith long-existing, chronic diseases, such as tuberculosis, long-continued suppurations, etc., in the abdominal organs, especiallythe spleen, liver, kidneys and lymphatic glands. This indicatesthat nutritional disturbances of the tissues, veiy gradually developedand profound, cause the cells to be put into the condition wheretheir proteid changes gradually into amyloid substance. Beyondwhat has been stated, amyloid metamorphosis remains still oneof the most enigmatical among the metamorphic processes, al-though it is wide-spread and possesses great importance inpathology. Finally, calcification is in a certain sense a counterpart to amy-loid metam
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