. The Biochemical journal, 1912. Biochemistry. 442 BIO-CHEMICAL JOURNAL cause a temporary paralysis of respiration. As compared with morphine, then, omnopon must be regarded as less toxic, and much less depressant to respiration. Nevei-theless, it decidedly depresses the reflex response to nervous stimulation, and, therefore, should be greatly superior to morphine in the treatment of Fig. II.—Cat. Urethane. Intestinal movements and blood pressure. Showing effect of a late injection of 2 Omnopon at A. Intestinal Movements. It is well known that morphine, probably during its excreti
. The Biochemical journal, 1912. Biochemistry. 442 BIO-CHEMICAL JOURNAL cause a temporary paralysis of respiration. As compared with morphine, then, omnopon must be regarded as less toxic, and much less depressant to respiration. Nevei-theless, it decidedly depresses the reflex response to nervous stimulation, and, therefore, should be greatly superior to morphine in the treatment of Fig. II.—Cat. Urethane. Intestinal movements and blood pressure. Showing effect of a late injection of 2 Omnopon at A. Intestinal Movements. It is well known that morphine, probably during its excretion, influences Auerbach's plexus in such a way as to diminish peristaltic movement. If, however, a large dose of morphine is suddenly thrown into the circulation the first effect is invariably augmented peristalsis, which in the case of man may lead to diarrhoea and vomiting. Narcotine shows this effect in a very much more pronounced way than morphine. This drug exerts no stimulant action on any form of plain muscle or motor nerve ending, but it has a markedly paralysing action on sympathetic ganglia; hence, it is not unreasonable to suppose that this action is due to depression of the ganglia on the course of the inhibitorv nerves to the Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Biochemical Society (Great Britain); University of Liverpool. Biochemical Dept. London [etc. ] Cambridge University Press
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