Dihydrofolate reductase and methotrexate. Computer model showing the structure of a human dihydrofolate reductase molecule (ribbons) bound to its cofa

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Dihydrofolate reductase and methotrexate. Computer model showing the structure of a human dihydrofolate reductase molecule (ribbons) bound to its cofactor nicotinamide adenine dinucleotide phosphate (NADPH, ball-and-sticks) and methotrexate (spheres). Dihydrofolate reductase is an enzyme that converts folic acid into a coenzyme. Methotrexate inhibits DHFR and is used in the treatment of cancer, autoimmune diseases and ectopic pregnancies.

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Size: 3623px × 4831px
Photo credit: © RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

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