. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. :;66 Kala-Azar are concerned as any associated growing bacteria quickly destroy them. Under conditions of cultivation the appearance of the organism undergoes a complete change. It enlarges, the nucleus increases greatly in size, and a pink vacuole appears near the blepharoplast. In the course of twenty-four to forty-eight hours the organism elongates, the blepharoplast moves to one end, and from the vacuole near it a flagellum is developed, and the orga
. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. :;66 Kala-Azar are concerned as any associated growing bacteria quickly destroy them. Under conditions of cultivation the appearance of the organism undergoes a complete change. It enlarges, the nucleus increases greatly in size, and a pink vacuole appears near the blepharoplast. In the course of twenty-four to forty-eight hours the organism elongates, the blepharoplast moves to one end, and from the vacuole near it a flagellum is developed, and the organism becomes in about ninety-six hours a flagellate protozoan resembling herpetomonas. It now measures about 20 n in length and 3 to 4 /i in breadth, its whip or flagellum measuring about 3 ^l, additional. It is also motile, and, like the trypanosomes, swims with the flagellum anteriorly. There is no undulating membrane. This may be regarded as the perfect or adult form of the organ- ism. It multiplies by a peculiar mode of division first observed by. Fig. 222.—Leishmania donovani. Flagellated forms obtained in pure cultures (Leishman). Leishman. Chromatin granules, a larger and a smaller, appear in the protoplasm in pairs, after which, through unequal longitudinal cleavage, long, slender, almost hair-like individuals, containing one of the pairs of chromatin granules, are separated. These were serpentine at first, but later, as they grew larger, a flagellum was thrust out at one end. Distribution.—The Leishman-Donovan bodies are widely distrib- uted throughout the body of the patients suffering from kala-azar. They occur in great numbers in the cells of the spleen, of the liver, of the bone-marrow, and in the ulcerations of the mucous membranes and skin. In the peripheral blood they are few and only in the leuko- cytes. They are always intracellular, or when in the circulating blood may be found in indefinite albuminous masses, probably de- stroyed cells. The number in a c
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectbacteri, bookyear1919
