. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 8 16 24 32 40 48 56 64 72 80 88 96 TIME OF TESTING (h). S£ 40 - L-i o TIME OF TESTING (h) Figure 1. Effects of inhibitors on the behavior tnut memory recall (us measured hv cluinge in body length) of Hermissenda. (A) Effects of ant- M>m\cin (ANI). Animals were trained with nine training events ana1 then tested for recall at 4 h post-training. For three groups of animals. ANI was added either immediatel\ after (curve ani4), or at 10 inin (curve ani4 +10) or 30 inin after the testing at 4 h Iciin'e ani4+30). Animals were th
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 8 16 24 32 40 48 56 64 72 80 88 96 TIME OF TESTING (h). S£ 40 - L-i o TIME OF TESTING (h) Figure 1. Effects of inhibitors on the behavior tnut memory recall (us measured hv cluinge in body length) of Hermissenda. (A) Effects of ant- M>m\cin (ANI). Animals were trained with nine training events ana1 then tested for recall at 4 h post-training. For three groups of animals. ANI was added either immediatel\ after (curve ani4), or at 10 inin (curve ani4 +10) or 30 inin after the testing at 4 h Iciin'e ani4+30). Animals were then relested at 8. 24. 48. and for some. 72 h for recall or retention of the training. Controls (con) were not treated with ANI. Data points below the -em line indicate foot contraction and positive recall of the training: positive numbers indicate body elongation as in normal locomotion with recall inhibition and blocked memory. (B) Combined results of the four inhibitors. actinom\cin-D (act-D). anisomycin (anil the tripeptide CAM inhibitor (rgd). and the sensory block (sh). Animals were treated as described in A. with the inhibitors added at the times indicated (on the graph) after the initial testing at 4 h. The animals were tested again for recall at 5. 6. or 8 h post-training. hihiting translation. It was administered at 1 ju,g/ml. The translation-inhibition was not checked. 3. Actinomycin-D (Act-D) interferes with mRNA synthesis by inhibiting transcription. It was administered at jug/ml. The transcription-inhibition was not checked. 4. ROD (arginyl-glycyl-aspartate) inhibits bond formation be- tween cell adhesion molecules (CAMs). It was administered at 10 /xg/ml. The bond formation inhibition was not checked. In the first experiment, specimens of Hermissenda were given nine TEs and tested at 4 h; this is the time at which our previous studies have shown recall to become insensitive to all four inhib- itors we are using, thereby showing that the stored memory is conso
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
