. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. Cellular Growth 131 A survey of the literature^''*'' on colchicine hints that moie examples could be obtained in which colchicine induces changes not directly correlated with a change in the number ot chromosomes. Obviously hundreds of polyploids have been induced by colchicine. Yet, along- side these majority reports come the difficult cases that appear as anomalous anatomical and morphological deviations. These are cer- tainly problems for futme study. : Metabolism and Colchicine Physiological studies w
. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. Cellular Growth 131 A survey of the literature^''*'' on colchicine hints that moie examples could be obtained in which colchicine induces changes not directly correlated with a change in the number ot chromosomes. Obviously hundreds of polyploids have been induced by colchicine. Yet, along- side these majority reports come the difficult cases that appear as anomalous anatomical and morphological deviations. These are cer- tainly problems for futme study. : Metabolism and Colchicine Physiological studies with colchicine that had some relation to c-mitosis were touched upon briefly in Chapter 3. At the basis of cellular changes such as c-tumors and cell differentiation there must also be phvsiological processes invohing action of colchicine. These are difficult to e\aluate. Howc\er, tests ha\e been run that show colchicine has a capacity to influence certain metabolic processes as iniderstood by special ^^- ^*'-' ^- Enzymatic reactions performed /// iiitro proved that the trans- formation of starch by malt diastase was accelerated. The basis for stimulation of this order was not explained, although as a constituent of the reaction medium, colchicine favored the rate of enzymatic action. Increasing the concentration of colchicine increased the rate of reaction correspondingly.^-' Diastase activity was scored by quantitative measurements of the increase in sugar (Benedict's solution) . Control \ alues were given at , and if the reaction time was accelerated, the value accord- ingly fell below \Vith each tenfold increase in concentration the rate was increased. V'alues of ± ± , and ± were obtained for three concentrations, 10 , 100 , and. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perf
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