. Cell physiology and pharmacology. Cells. ANALYSIS OF DRUG ACTION 8i The analysis is further compHcated by the occurrence of very marked species differences. For example, when we take the inhibitory action of HCN on cellular processes or say the lethal action of HgS, it is tempting to work on the hypothesis that in all cases the drug is acting on the same enzyme system, but Figs. 15 and 16 show that the concentrations required to produce a given degree of 100. log [HiS] Fig. 16. The relationship between concentration of H2S and its lethal action on the spores of eight different species of fun
. Cell physiology and pharmacology. Cells. ANALYSIS OF DRUG ACTION 8i The analysis is further compHcated by the occurrence of very marked species differences. For example, when we take the inhibitory action of HCN on cellular processes or say the lethal action of HgS, it is tempting to work on the hypothesis that in all cases the drug is acting on the same enzyme system, but Figs. 15 and 16 show that the concentrations required to produce a given degree of 100. log [HiS] Fig. 16. The relationship between concentration of H2S and its lethal action on the spores of eight different species of fungi, (a) Venturiain- equalis and Uromyces caryophyllinus; (b) Puccinia antirhini; (c) Sclerotina americana: (d) Macrosporidium sarcinaeforme; (e) Pestolatia stellata; (f) Glomerella cingulata; (g) Botrytis action vary widely from species to species. Various ex- planations of this are possible. It may be that the drug does not produce its effect by acting on the same en- zyme in all species. Or it may be that a given enzyme in different species varies in its susceptibility to a given drug. A third possibility is that the effective concen- tration of the drug which arises in the vicinity of the enzyme is different in different cells, although the ex- ternal concentration of drug is the Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Danielli, J. F. (James Frederic), 1911-. New York, Elsevier
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