Embryology (1949) Embryology embryology00bart Year: 1949 REGION OF DEDIFFERENTIATE V//////////< — °°o %%%%%%%%%%%%%%%% 11< vzzzzzzzzzl*-*\Y° COMPLETED REGENERATION Fig. 160. Schematic representation of the cellular changes after cutting the limb of a larval salamander. Top: A clean cut traverses epidermis, dermis, con- nective tissue, muscle, and bone (nerves and blood vessels not shown). Next lower: A blastema forms. The exact origin is not known. We have represented the blastema as forming from the dedifferentiated cells of the various tissues of the limb plus cells which migrate i
Embryology (1949) Embryology embryology00bart Year: 1949 REGION OF DEDIFFERENTIATE V//////////< — °°o %%%%%%%%%%%%%%%% 11< vzzzzzzzzzl*-*\Y° COMPLETED REGENERATION Fig. 160. Schematic representation of the cellular changes after cutting the limb of a larval salamander. Top: A clean cut traverses epidermis, dermis, con- nective tissue, muscle, and bone (nerves and blood vessels not shown). Next lower: A blastema forms. The exact origin is not known. We have represented the blastema as forming from the dedifferentiated cells of the various tissues of the limb plus cells which migrate in from the epidermis. Third figure: What- ever the exact origin of the blastema, the process of dedifferentiation is soon checked and then cells of the blastema begin to re-differentiate into muscle, bone, etc. Bottom: Regeneration completed. The blastema has differentiated into the missing part. 237
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