Clinical lectures on the principles and practice of medicine . could be squeezed out of its capsule. Inten cases the spleen contained yellow fawn-colored discolorations withabrupt margins, sometimes diffused in masses varying in size from awalnut to that of a hens egg, at others, disseminated in miliary spotsthrough the organ. In two cases, these altered masses of the spleenssubstance had softened and burst into the peritoneum, causing fatalperitonitis. In another case, a distinct line of separation was observedto be forming round a mass about the size of a walnut. On examining this altered te
Clinical lectures on the principles and practice of medicine . could be squeezed out of its capsule. Inten cases the spleen contained yellow fawn-colored discolorations withabrupt margins, sometimes diffused in masses varying in size from awalnut to that of a hens egg, at others, disseminated in miliary spotsthrough the organ. In two cases, these altered masses of the spleenssubstance had softened and burst into the peritoneum, causing fatalperitonitis. In another case, a distinct line of separation was observedto be forming round a mass about the size of a walnut. On examining this altered texture in the spleen with a power of 350diameters linear it was found to consist of—1st, numerous molecules andgranules; 2d, free nuclei; 3d, compound granular cells of various sizes ;4th, fragments of the fibrous tissue and fusi-form corpuscles of the organ. The cells were frequently ruptured, more or less r::yf^\-:^\ broken down, and appeared to ine at that time : .., ,.,., .i,-j-,.i,.n.„ ..a ,j—..„i „i _,.,., „x- „. .; si to constitute the structural character of a new\i %!$£ ^ formation which had been described by Roki-(!!%r tanski and other German pathologists, as ty-phus deposit. This deposition, according tothem, bears the same relation to the constitu-xi! 525. Fig. 523. tion of the blood in cases of typhus fever, as tubercle and cancer do to the tubercular and cancerous cachexise. Al-though the facts described by Rokitanski and others are quite correct,as well as his description of the structure of this altered tissue which Iconfirmed in 1847—48, further observation has convinced me that thesealterations are not peculiar to typhus, and do not constitute a distinctform of exudation. They consist, in point of fact, of a peculiar de-generation of the splenic pulp, which follows a greater or less increasedgrowth of the glandular cells, the morbid anatomy of which is displayedin a series of preparations I placed in the University Mu
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Keywords: ., bookcentury1800, bookdecade1870, booksubjectmedicine, bookyear187
