. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. ISLET-subclass LMX-subclass LHX3/4-subclass c-Lim-1 Xlim-1 zf-Lim-1 Xlim-5/Xlim-2 |_HX1/5-SUt>ClaSS zf-Lim-5 LIN-11 Dm-Bk87 MEC-J Dm-apterous >pt< h-LH-2 AP-subclass. •j\ sensory cells interneurons I 5 motor dauer program output (metabolic control) Figure 1. Dendrogram of LIM homeodomain proteins. Figure 2. The neural thermoregulatory pathway in Caenorhabditis elegans. lar to thermocontrol in vertebrates. The major thermoreg- ulatory organ of vertebrates, the hypothalamus, contains distinguishable warm- and cold-sen
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. ISLET-subclass LMX-subclass LHX3/4-subclass c-Lim-1 Xlim-1 zf-Lim-1 Xlim-5/Xlim-2 |_HX1/5-SUt>ClaSS zf-Lim-5 LIN-11 Dm-Bk87 MEC-J Dm-apterous >pt< h-LH-2 AP-subclass. •j\ sensory cells interneurons I 5 motor dauer program output (metabolic control) Figure 1. Dendrogram of LIM homeodomain proteins. Figure 2. The neural thermoregulatory pathway in Caenorhabditis elegans. lar to thermocontrol in vertebrates. The major thermoreg- ulatory organ of vertebrates, the hypothalamus, contains distinguishable warm- and cold-sensing temperature pro- cessing units (8) that may be homologous to the antago- nistic high and low temperature sensing pathways of the C. elegans thermotactic response pathway (Fig. 2). The vertebrate ttx-3 homolog Lhx2 and the lin-ll homolog Llixl are indeed expressed in the diencephalon, which gives rise to the thermoregulatory hypothalamus (9, 10). lin-ll and tlx-3 in C. elegans, and their homologs in mammals, may thus play a similar role in the development of two components of these related thermal processing networks. Apart from their suggested role in the hypothalamus, the vertebrate lin-ll and ttx-3 homologs Lhxl and Llix2 are expressed in several additional places in the nervous system (9, 10). The additional roles of the vertebrate genes might parallel the function of the nematode homo- logs, making additional cases for a conservation of func- tion throughout evolution. For example, lin-ll is ex- pressed and functions in the ventral nerve cord of C. elegans, where it is required for correct axon bundle fasciculation (7); vertebrate Lhxl is similarly expressed in motor neurons of the spinal cord. Additionally, Lhxl expression can be observed in sensory structures in the. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
