Diseases of the nervous system : a text-book of neurology and psychiatry . ally all of the bones of the skeleton. Amenorrhea isfrequent in women and loss of potency in men. Glycosuria is tolerance may be high, however, and an increasedfondness for sweets is frequent. Symptoms.—In addition to the essential metabolic disturbance,symptoms due to the nature of the producing lesions—tumor, hyper-plasia, i. e., neighborhood symptoms, are frequently found, but theseare not 162 , THE ENDOCRINOPATHIES Severe bitemporal headaches are frequent. This is an intracranialp
Diseases of the nervous system : a text-book of neurology and psychiatry . ally all of the bones of the skeleton. Amenorrhea isfrequent in women and loss of potency in men. Glycosuria is tolerance may be high, however, and an increasedfondness for sweets is frequent. Symptoms.—In addition to the essential metabolic disturbance,symptoms due to the nature of the producing lesions—tumor, hyper-plasia, i. e., neighborhood symptoms, are frequently found, but theseare not 162 , THE ENDOCRINOPATHIES Severe bitemporal headaches are frequent. This is an intracranialpressure sign. The sella turcica is usually enlarged from tumorformation, and this is readily seen by a:-ray. Pressure upon the optic nerves at the chiasm is usual, leading tovarious types of hemianopsia. Distorted fields are the rule. Pupillaryphenomena are frequent, and visual defects are often serious andprogressive. Mental symptoms ranging from sluggishness to complete deteriora-tion occur, but are not invariable. Other of the endocrinous glands may show Fig. 55.—Characteristic hand of acromegaly. Note heaping of tissues about nails,type en large of Marie. Compare with Fig. 56. (From Cushings PituitaryBody.) Prognosis.—This is always grave. The disorder is progressive, usu-ally very gradual, five to twenty years, but the advance in symptomsmay be arrested. Hypopituitarism.—Deficiency of the hypothetical pituitary substancegives rise to a group of syndromes the most classical of which isFrohlichs dystrophia adiposogenifalis. This is characterized by aprogressive accumulation of fat throughout the body, chiefly showingabout the buttocks and breasts, and by a lack of development of theprimary and secondary sexual characters. Thus there is a stunting of the growth physical and mental, ahypoplasia genitalis, and a failure to develop the voice, the mammaeand the scrotum or testicle. As a rule there is a fairly persistent DISEASES OF THE HYPOPHYSIS—PITUITARY 1
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