. Endocrinology. leven months, without somatic signs of castration temporary regeneration of generative tissue as probably occur-ring in testicular fragments might indeed have interfered andby this the maintenance of the sex characteristics might be ex-plained. But no proof exists that such a regeneration alwaystakes place. Tiedje (12) assumed that there is, after a degenera-tion of the tubules has taken place, a pause in the endocrine func-tion of the testicle till regeneration occurs; but this is whollyerroneous, since out of a great many cases I only once observed LIPSCHUTZ 9 te
. Endocrinology. leven months, without somatic signs of castration temporary regeneration of generative tissue as probably occur-ring in testicular fragments might indeed have interfered andby this the maintenance of the sex characteristics might be ex-plained. But no proof exists that such a regeneration alwaystakes place. Tiedje (12) assumed that there is, after a degenera-tion of the tubules has taken place, a pause in the endocrine func-tion of the testicle till regeneration occurs; but this is whollyerroneous, since out of a great many cases I only once observed LIPSCHUTZ 9 temporary cessation of the endocrine function of the fragmentwith following resumption of endocrine activity. (2) A second possibility would be that the testicle can,indeed, perform its normal hormonic function without the dif-ferent stages of spermatogenesis being present, but that sperma-togenesis is necessary for the development of the interstitial cellsto an organ of internal secretion. If we compare the animal. Fig. 5. Section tlirough the testicle of a normal animal of the same litteras Fig. 4. Seminal tubules in full spermatogenesis (not drawn). Normal inter-stitial cells. Fixation and stain, as Fig. 3. Fig. 6. Scale of magnification. No. 4 with No. 30 such an assumption becomes very No. 4 we have infantile tubules and infantile interstitial cellswith eunuchoidism; in No. 30 we have tubules regressed to aninfantile stage and adult interstitial cells with sexusl taking into consideration only the actual state of the testisone must conclude that the different result is caused by differ-ence in the state of the interstitial ceUs, but taking into considera- 10 SEAT OF ENDOCRINE FUNCTION OF TESTICLE tion what had happened in the testis of both cases in the courseof several months, one cannot exclude the possibility that begin-ning spermatogenesis, if indeed not a complete cycle, was neces-sary for the development of active interstitial cells. By such a
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectendocrinology, bookye
