. Biological time. Life (Biology); Time; Wounds and injuries; Tissue culture; Biological Clocks; Biology; Philosophy, Medical; Wounds and Injuries. 58 PRELIMINARY EXPERIMENTS (these experiments were made before the use of the plani- meter) decreased by 20 millimetres (a little less than one third), whereas the length of the small one decreased by only 4 milHmetres, about one sixth. For the same reason^ when the wounds were of trapezoidal Distance oc^ Quiescent "pariod. -â ^^ p«,riool ^; -^. Epitheri-sahonJk- ptnooL '^ .^^J- <yz/////y^ C\c 10 IS 10 25 FIG. I. (experime
. Biological time. Life (Biology); Time; Wounds and injuries; Tissue culture; Biological Clocks; Biology; Philosophy, Medical; Wounds and Injuries. 58 PRELIMINARY EXPERIMENTS (these experiments were made before the use of the plani- meter) decreased by 20 millimetres (a little less than one third), whereas the length of the small one decreased by only 4 milHmetres, about one sixth. For the same reason^ when the wounds were of trapezoidal Distance oc^ Quiescent "pariod. -â ^^ p«,riool ^; -^. Epitheri-sahonJk- ptnooL '^ .^^J- <yz/////y^ C\c 10 IS 10 25 FIG. I. (experimental WOUND IN THE UPPER RIGHT-HAND CORNER.) POINTS A AND B ARE ON THE OUTLINE TATTOOED WITH INDIA INK. POINTS a AND p ARE ON THE NEWLY FORMED EPITHELIAL BORDER. THE SCHEMATIC CURVE SHOWS THE SUCCESSIVE PHASES OF CICATRIZATION. ORDINATES EXPRESS THE DISTANCE BETWEEN POINTS A AND B (SOLID CURVE) AND a AND ^ (DOTTED CURVE) AS A FUNCTION OF TIME shape, the length of the longer base tended to equahze itself with that of the smaller one and the wounds became rectangu- lar in a few days. The same results were obtained with circular wounds made by punching out the skin. It was then estabHshed that the rate of reparation during the granular period was a function of the dimension of the wound, that is to say, of the total effort required to repair the destroyed area. This law had already been estabUshed by Spallanzani for salamanders.^ It was thus proved to be equally true for mammals. This was unforeseen considering the differences of the mechanisms brought into play. Minervini, in 1904," had found the same phenomena. However, as he made no measurements, he did not conceive the existence of the curve ^ Spallanzani J Experiences pour servir a Vhistoire de la generation des animaux et des plantes (1787). 2 Minervinij Virchows Ann., vol. 175^ p. 238 (1904).. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability -
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