Trypanothione reductase complexed with TRL149 inhibitor

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Molecular model of Trypanothione reductase complexed with triazolium based inhibitor TRL149. Trypanothione reductase enzyme is essential for the redox functioning of Leishmania infantum, the causative agent of Leishmaniasis. TRL149 binds to the outer part (spheres) of Trypanothione reductase, preventing the activity of this essential enzyme for Leishmania infantum. Protozoans Leishmania and Trypanosoma, belonging to the same Trypanosomatidae family, are the causative agents of Leishmaniasis, Chagas disease, and human African trypanosomiasis.

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Photo credit: © RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

Keywords: -, 6t95, background, biochemical, biochemistry, biological, biology, black, crystallography, design, discovery, drug, infantum, infection, leishmania, molecular, molecule, parasites, parasitic, protein, protozan, protozoa, rational, reductase, structure-based, triazole, triazolium, trl149, trypanosomatid, trypanothione