AMAarchives of neurology & psychiatry . s already been reported (Hassin, G. B.: Histo-pathology of Carcinoma of the Cerebral Meninges, Arch. Xeurol & :705 [Tune] 1919). The second was furnished by Dr. William Thalhimer ofMilwaukee. We are indebted to Dr. Peter Bassoe of Chicago for the oppor-tunity to study four and to the Cook County Hospital for two carcinomas inthe brain. All showed metastases ; two were carcinomas of the lungs, two ofthe uterus, one of the pancreas, one of the breast, one of the intestine and oneprobably of the prostate. HASSIX-SIXGER—CEREBRAL CARCIXOMA 157 MACRO
AMAarchives of neurology & psychiatry . s already been reported (Hassin, G. B.: Histo-pathology of Carcinoma of the Cerebral Meninges, Arch. Xeurol & :705 [Tune] 1919). The second was furnished by Dr. William Thalhimer ofMilwaukee. We are indebted to Dr. Peter Bassoe of Chicago for the oppor-tunity to study four and to the Cook County Hospital for two carcinomas inthe brain. All showed metastases ; two were carcinomas of the lungs, two ofthe uterus, one of the pancreas, one of the breast, one of the intestine and oneprobably of the prostate. HASSIX-SIXGER—CEREBRAL CARCIXOMA 157 MACROSCOPIC APPEARANCE OF THE TUMORS The tumors appeared as foci of varying size scattered irregularlythrough the gray and white substance, sometimes transgressing thepia. They were well defined, loosely attached to the surrounding tissuesand extremely soft. The smaller foci were more solid and suitablefor frozen section. In one case there was a single metastatic tumorinvolving the area of the basal ganglions, extending into the third. Fig. 1.—Demarcation zone , dividing the brain below from the cancerfoci above; B, bands of connective tissue enveloping the larger focus; C, aganglion cell invaded by cancer cells (reproduced under higher power in Figure3). Thionin; X 125. ventricle, corpus callosum, cortex and almost reaching but not invadingthe pia. Here the afifected areas were separated from the noncanceroustissue by a well marked zone of demarcation (Fig. 1). MICROSCOPIC EXAMIXATIOX The microscopic appearance of the invaded area, the zone ofdemarcation and the cerebral tissue adjacent to and remote from the 158 ARCHllES or XIirROLOGV AXD PSYCIIIArRY tumor (liiiferecl from one another. The histology of the carcinomaneeds no description; we shall limit attention to the brain tissues. The Invaded Area.—This ])resented an areolar a])pearance withislands of cells separated l)y l)ands of connective tissue ( Fig. 1 ). 1 were for the most ])art ganglion cells in var
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