. The endocrine organs; an introduction to the study of internal secretion . s will be missed; but the loweredtemperature, the tolerance to sugar, and the supervention of excessiveadiposity are generally present, as well as dryness of skin and loss ofhair, besides a tendency in the male to adopt the feminine type of trichosis,even in cases where the male type has already been established. Accordingto Gushing, pigmentation of the skin is a conspicuous feature of many ofthe adult states, and as it is apt to be associated with asthenia or a lowblood-pressure it is natural to ascribe it to an asso
. The endocrine organs; an introduction to the study of internal secretion . s will be missed; but the loweredtemperature, the tolerance to sugar, and the supervention of excessiveadiposity are generally present, as well as dryness of skin and loss ofhair, besides a tendency in the male to adopt the feminine type of trichosis,even in cases where the male type has already been established. Accordingto Gushing, pigmentation of the skin is a conspicuous feature of many ofthe adult states, and as it is apt to be associated with asthenia or a lowblood-pressure it is natural to ascribe it to an associated adrenal insuffici-ency, though it hardly reaches the degree of bronzing seen in some of theAddisonian examples of adrenal tuberculosis. As has already been stated, the history of some cases of affections ofthe pituitary shows symptoms characterising hypopituitarism followingthose characteristic of hyperpituitarism, although of course little or no 1 Gushing has pointed out that these symptoms closely resemble those which occur inanimals about to undergo FIG. 79.—Case of pituitary infantilism.(Byrom Bramwell.) The patient was27 when the photograph was height was 4 feet 1| the arrested development ofthe sexual organs, the deficiency ofhair, the adiposity, the slender limbsand digits, and the general approachto the feminine type of body. 112 The Endocrine Organs retrogression in the growth of the skeleton and body can generally beexpected. Thus the occurrence of hyperplasia and hyperpituitarism duringadolescence leading to a general overgrowth of the body and unusual growthof hair, and sometimes accompanied by sexual precocity, may be followedby glandular hypoplasia and diminution of the sexual instinct evenproceeding to impotence; as well as by excessive adiposity and the
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