Archive image from page 327 of Currents in biochemical research (1946). Currents in biochemical research currentsinbioche00gree Year: 1946 ( GREGORY PINCUS fate of the corticosteroids in the organism. We have mentioned that desoxycorticosterone is degraded in part to pregnanediol. No parallel information is available for the other active corticoids such as VII and VIII, largely because these substances are available as pure CH2OH CH2OH 0= -\/\ (VII) Corticosterone c=o OH (VIII) ll-Dehydro-17-hydroxycorticosterone chemicals in only very small amounts. (They have been obtainable thus far onl
Archive image from page 327 of Currents in biochemical research (1946). Currents in biochemical research currentsinbioche00gree Year: 1946 ( GREGORY PINCUS fate of the corticosteroids in the organism. We have mentioned that desoxycorticosterone is degraded in part to pregnanediol. No parallel information is available for the other active corticoids such as VII and VIII, largely because these substances are available as pure CH2OH CH2OH 0= -\/\ (VII) Corticosterone c=o OH (VIII) ll-Dehydro-17-hydroxycorticosterone chemicals in only very small amounts. (They have been obtainable thus far only from adrenal gland extracts and the yields are very low.) Although we know that they are very rapidly inactivated in vivo, their breakdown products are unknown. It is suspected that certain of them may be converted to 17-ketosteroids, since adrenalectomy or atrophy of the adrenals leads to a marked reduction in urinary 17-keto- steroid output; but since other possible precursors of 17-ketosteroids have been isolated from adrenal tissue {e. g., androstenedione) experi- mental verification is needed. Eventually we shall have a detailed description of steroid hormone transformation in animals and of the particular enzyme systems involved. If we are to know the extent to which such trans- formations are tied up with the function of the hormones, we will have to know not only more about these metabolic changes but also the precise role of the steroid hormones in cellular processes. Role of Steroid Hormones in Cellular Processes There is an extensive literature containing qualitative and quantitative data on the effects of administering steroid hormones to animals. It is not possible as yet to interpret these effects in terms of the chemistry of the cell. Thus, the remarkable growth of vaginal epithelium induced in spayed animals by folliculoids has been rather intensively studied. That it can be induced by the direct application 316
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