. The endocrine organs; an introduction to the study of internal secretion . al observations on the effects of destructive disease of thepituitary, it must be regarded as doubtful whether the removal of the glandhas been as complete in these cases as in those described by Paulesco andGushing, the operative method employed by whom seems less open to objec-tion than that in which the gland is reached through the basi-sphenoid. EFFECTS OF PARTIAL REMOVAL AND INJURY The results of lesions which involve only partial removal are even more interesting than those inwhich the extirpation is completeand
. The endocrine organs; an introduction to the study of internal secretion . al observations on the effects of destructive disease of thepituitary, it must be regarded as doubtful whether the removal of the glandhas been as complete in these cases as in those described by Paulesco andGushing, the operative method employed by whom seems less open to objec-tion than that in which the gland is reached through the basi-sphenoid. EFFECTS OF PARTIAL REMOVAL AND INJURY The results of lesions which involve only partial removal are even more interesting than those inwhich the extirpation is completeand the symptoms more most striking effects are ob-tained in young animals. Re-tardation of growth after hypo-physectomy has been describedby various authors, and that thisis a characteristic of diminishedamount of pituitary substanceand concomitant diminishedsecretion of autacoids by thegland has been established by theexperiments of Gushing and ofBiedl. The work of Aschner,which has already been alludedto, also obviously has an im-portant bearing upon this point,. FIG. 70.—Twelve-months-old hypophysectomiseddog (left) and control of same litter (right).(Aschner.) The operation was performed ateight weeks. although Aschner himself be-lieves that in most of his operations the removal was complete and thatthe condition was one of apituitarism. The retardation in developmentshows itself in a general diminution in size, in the ossification process,which is imperfect, and in the sexual organs, which long retain theirinfantile condition. Mental dullness has also been generally noted. In spite of retardation in development, there is a marked tendency tofat formation, so that the actual weight of the operated animal may exceedthat of the control. Even in adult animals a tendency to obesity is acharacteristic feature after partial hypophysectomy. Accompanying thistendency, and possibly acting as a causative agent, is a high tolerance forsugars, the limit of alimentary glycosur
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