. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. 76 H. S. SiMMS, B. N. Berg, and D. F. Davies The reason why the curves fall off after reaching a maximum is simply that there are fewer remaining animals without lesions of a given disease and which consequently can acquire lesions for the first time. There is no decrease in the tendency to form lesions among those individuals that have survived to advanced age without them. This is shown in Fig. 4, where it is seen that the tendency to form lesions increases progressively with age. —. AGE IN DAYS 0- 10
. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. 76 H. S. SiMMS, B. N. Berg, and D. F. Davies The reason why the curves fall off after reaching a maximum is simply that there are fewer remaining animals without lesions of a given disease and which consequently can acquire lesions for the first time. There is no decrease in the tendency to form lesions among those individuals that have survived to advanced age without them. This is shown in Fig. 4, where it is seen that the tendency to form lesions increases progressively with age. —. AGE IN DAYS 0- 100 200 —1 r- ^iL5 3di ^>- ^ Fig. 5. Logarithm of the probabihty of onset of new lesions (among surviving rats having no lesions). Also a curve for rat mortality (From Simms and Berg, 1957). That this increase is a logarithmic function of age is shown in Fig. 5, where the logarithm of the probability of onset (among rats not having lesions) is plotted against age. These curves approximate to straight lines. Note that they parallel the bottom curve for mortality of rats. We may now compare rat and man. Fig. 6 contains two charts each having data from both rat and man. At the left end of the top chart are curves for occurrence of lesions in rats. These are identical with the curves in Fig. 2, except that here the time scale is very much condensed, making the curves much steeper. Similarly, at the left end of the bottom chart are curves for the distribution of onset of lesions in. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward). Boston, Little, Brown
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