Studies in cardiac pathology . xperimental nephritis produced by cold, adren-alin is found in increased amounts in the blood immediately succeeding the coldbath, indicating that perhaps this substance is the cause of the hypertension inthe early stages of the natural disease. Hypertrophy in Valvular Disease.—The myocardial changeswhich follow experimental section of the aortic and tricuspidvalves indicate a mechanical and not an inflammatory primary dilatation which follows the operation produces first Bronowski: Presse M6dicale, 1904, No. Alwen: Deut. Arch. f. klin. Med., xcvi
Studies in cardiac pathology . xperimental nephritis produced by cold, adren-alin is found in increased amounts in the blood immediately succeeding the coldbath, indicating that perhaps this substance is the cause of the hypertension inthe early stages of the natural disease. Hypertrophy in Valvular Disease.—The myocardial changeswhich follow experimental section of the aortic and tricuspidvalves indicate a mechanical and not an inflammatory primary dilatation which follows the operation produces first Bronowski: Presse M6dicale, 1904, No. Alwen: Deut. Arch. f. klin. Med., xcviii, 137. ^ Heinike and Paessler: Verhandl. d. deutsch. path. Gesellsch., 1905, p. 99.^ Jores: Verhandl. d. deutsch. path. Gesellsch., 1908, p. ^ Schur and Wiesel: Verhandl. d. deutsch. path. Gesellsch., 1907, p. Asohoff and Cohn: Verhandl. d. deutsch. path. Gesellsch., 1908, p. 31. Goldschmidt:Deut. Arch. f. klin. Med., xcix, 186. Pearce: Jour. Med. Research, 1908, 2. Reicher: Berlin, klin. Woch., 1908, No. Fig. 49.—Left Ventricular Hypertrohpy. A of aortic and mitral stenosis. The aortic valves have unfortunately been destroyedthrough handling. The mitral valve shows marked induration oj the leaflets and chordw tendinem,together with a Jew old fibrous vegetations. The papillary muscles are hyperlrophied. (Specimenfrom the German Hospital, Philadelphia.) 154 STUDIES IN CARDIAC PATHOLOGY an increase of connective tissue, later a muscular changes may occur independently of each other. ^ This isopposed to the older teaching of Albrecht, whose views werebased upon a study of human hearts, mostly in cases of nephritis,in which condition serositis and other inflammatory^ changes arecommon. TangP has shown that even in the most emaciatedanimals hypertrophy of the left ventricle will develop after arti-ficially produced valvular lesions. Hypertrophy is a result of the prolonged overexertion of theheart muscle which is required to supply the
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