. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ge of doses of adre- Inllestine ^^^^Hf^f^m^^f^f^i^^^ Spleen Zero Fig. 6. Dilatation in spleen, and constriction in intestine, after small dose of adrenalin( cc, 1 : 10,000). Dog 21 (Reduced f) nalin employed. This constriction was more marked and more pro-longed as the doses were increased in magnitude (see figs. 5 and 7).The three others each gave dilatation at some dose of of the three showed as a first effect dilatation with small doses;or, to speak more accurately, small doses of adrenalin set u
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ge of doses of adre- Inllestine ^^^^Hf^f^m^^f^f^i^^^ Spleen Zero Fig. 6. Dilatation in spleen, and constriction in intestine, after small dose of adrenalin( cc, 1 : 10,000). Dog 21 (Reduced f) nalin employed. This constriction was more marked and more pro-longed as the doses were increased in magnitude (see figs. 5 and 7).The three others each gave dilatation at some dose of of the three showed as a first effect dilatation with small doses;or, to speak more accurately, small doses of adrenalin set up in these DIFFERENTIAL ACTION OF ADRENALIN 319 spleens (which had previously been relatively inactive) a series of waves,of which the first was in the direction of dilatation (see fig. 6). Inboth these organs the effect of increasing the dose was to increase theconstriction in the waves at the expense of the dilatation, until largedoses caused only decrease in volume. In the third of these spleensdoses of adrenalin also set up series of waves, but its reaction differed. Fig. 7. Effect on same animal as that of figure 6, of a larger dose (1 cc, 1:10,000);slight dilatation followed by marked constriction in spleen, preliminary constrictionand marked dilatation in intestine (Reduced 5) from that of the other two in that, on administration of relativelylarge doses ( cc, 1 : 100,000 per kilogram) the constriction wasfollowed by dilatation. KIDNEY The upper part of the ureter and the kidney vessels of one sidethroughout their entire length were dissected out to form a stalk. Themesentery was removed as gently as possible from the surface of the 320 FRANK A. HARTMAN AND LOIS MCPHEDRAN kidney. A few of the larger veins runningwere ligatured. During the dissection thecompletely as possible with warm pads. Four experiments in all were performed,dogs. In every case injections of adrenalinkidney (see figs. 8 and 9); with small doses from it into the capsulekidney was protected as two o
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