. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 990 ADVENTURES IN RADIOISOTOPE RESEARCH together with mgm of inorganic phosphorus, ^2? of negligible weight and having an activity oi 1 fic moves into the corpuscles, after injection of the labelled corpuscles into an inactive circulation the migration of mgm of inorganic P from the red corpuscles into the plasma will be followed by that of about f^c. only (cf. Figs. 11 and 12). This is because most of the ^2? (and ^iP) after having penetrated into the red corpuscles finds a temporary abode in the organic ph
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 990 ADVENTURES IN RADIOISOTOPE RESEARCH together with mgm of inorganic phosphorus, ^2? of negligible weight and having an activity oi 1 fic moves into the corpuscles, after injection of the labelled corpuscles into an inactive circulation the migration of mgm of inorganic P from the red corpuscles into the plasma will be followed by that of about f^c. only (cf. Figs. 11 and 12). This is because most of the ^2? (and ^iP) after having penetrated into the red corpuscles finds a temporary abode in the organic phosphorus compounds. Plasma Red corpuscles Fig. 11. — Distribution of inorganic phosphate intruded into the red corpuscles between organic and inorganic fractions Fig. 12. — Interchange of ^^P and 22p between plasma and red corpuscles + 0,7 mg ^'P I I 0,7 mg ^'P I microcurie-''P 0,7 mg ^'P I 0,7mq^'P _-^ H ? IQ microcune ?^'P present in the erythrocytes. About 1/10 represents the ratio of the inor- ganic P content of the plasma and labile P content of the red corpuscles. This ratio, and correspondingly the time during which ^2? is kept in the erythrocytes, may vary for the blood of different subjects. The perme- ability of the red corpuscle membrane, which is also of importance for the temporary conservation of 32p in the corpuscles, may vary as well. The loss of the ^ap content of the corpuscles in the course of 20 minutes is, however, in no case larger than 3%, and in most cases even appreci- ably less. When not labelled corpuscles but labelled blood is injected into the circulation, loss of ^sp by the corpuscles during the experiment can furthermore be compensated to an appreciable extent by uptake of 32P from labelled plasma present in the circulation. (?"> Ark. Kemi 20, A Nr. 17 (1945); cf. Reeve and Veall, J. Physiol. 108, 12 (1949).. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - col
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