. The American journal of anatomy. ed development of the islandat the period corresponding topreparation No. 10. At thisperiod (third month) theamount of connective tissue inthe normal pancreas is verygreat, and the rapid prolifera-tion of the glandular portion of the pancreas characteristic of the fifth and sixth months has not com-menced. Syphilis of the pancreas has been observed as early as thefifth month (Miiller, 16), but there are no observations to prove thatit does not occur earlier. The increase of connective tissue, which isthe characteristic lesion in the pancreas, causes not only
. The American journal of anatomy. ed development of the islandat the period corresponding topreparation No. 10. At thisperiod (third month) theamount of connective tissue inthe normal pancreas is verygreat, and the rapid prolifera-tion of the glandular portion of the pancreas characteristic of the fifth and sixth months has not com-menced. Syphilis of the pancreas has been observed as early as thefifth month (Miiller, 16), but there are no observations to prove thatit does not occur earlier. The increase of connective tissue, which isthe characteristic lesion in the pancreas, causes not only an atrophyof existing glandular structures, but what is more important, preventsthe further development of the gland. The glandular tissue is repre-sented by small, irregularly scattered gland groups; the ducts are promi-nent; the islands are arrested at the stage in which they are still con-nected with the acini. The microscopic picture of the normal pancreasat the end of the third month is very similar to the syphilitic pancreas. m N^iT^. 9^, Fig. 3. Syphilitic pancreatitis in a foetus ofthe seventh month. Arrested development ofthe island; the persisting- solid process ofcells still connects the island with the glandu-lar acinus. ^ Opie, in his account of two cases of congenital syphilis, describes and picturesthis condition. 31 454 The Islaiuls oi Jjangerhans in the liunian Embryo at the sixth or seventh month, except that the latter has a larger pro-portion of connective tissue. In other words, at the latter period, wehave the development of the third month plus the connective tissue pro-duced by the syphilitic process. This arrest of development is shown inFig. 3, which is taken from a specimen of syphilitic pancreatitis in afoetus 21 cm. long. Summary.—The islands of Langerhans (embryo of 54 mm.) originatethrough a proliferation and differentiation of the cells of tin; primitivesecreting tubules. The differentiated cells characterized by a rich, finelygranular, eosinop
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectanatomy, bookyear1901
