Transactions of the Royal Society of Edinburgh . our, .... 1-9 cc. 2-5 cc. It appears from this analysis that the bile secreted under the influence ofleptandria retained its normal composition. Results of Experiments with Leptandria.—Leptandria is a feeble hepaticand intestinal stimulant. Notwithstanding the large doses employed, thehourly coefficient of secretion did not rise above 0*316 cc. The bile has thenormal composition. As in the case of other resinous matters, the absence ofthe biliary solvent from the duodenum greatly lessens the effect (Experi-ment 32). Action of Resina Sanguinary,
Transactions of the Royal Society of Edinburgh . our, .... 1-9 cc. 2-5 cc. It appears from this analysis that the bile secreted under the influence ofleptandria retained its normal composition. Results of Experiments with Leptandria.—Leptandria is a feeble hepaticand intestinal stimulant. Notwithstanding the large doses employed, thehourly coefficient of secretion did not rise above 0*316 cc. The bile has thenormal composition. As in the case of other resinous matters, the absence ofthe biliary solvent from the duodenum greatly lessens the effect (Experi-ment 32). Action of Resina Sanguinary, ok Sanguinarin. Dr Wood {Op. xi. p. 367) states that, although the Sanguinaria cana-densis has been used more or less for so many years, we are still without anyreally definite knowledge of its action. Little or nothing has been added toour knowledge since the papers by Dr Tully in 1830, who stated that whengiven in small repeated doses it acts as a very decided cholagogue; and more PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 179. recently it has been affirmed that it is also a stimulating full doses it is certainly a harsh emetic, and in overdoses, according toTully, it produces with the vomiting, burning at the stomach, faintness,vertigo, dimness of vision, general insensibility, coldness, extreme reduc-tion of the force and frequency of the pulse, great prostration of the muscularstrength, and sometimes a convulsive rigidity of the limbs. Dr Woodstates that he has never known of its employment except as a stimu-lant expectorant in obstinatebronchitis. Dr Mothershead,of Indianapolis (quoted in p. 741) however speaks inthe strongest terms of its effi-cacy as an excitant of the liver,when given in alterative the other hand, ProfessorThomas of Philadelphia (quotedin Op. x. p. 742), found theactive principle sanguinarina tohave no effect of any kinddirectly on the liver of man. Sanguinarin is, however, re-commended by the American Ecle
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