. The actinomycetes. Actinomycetales. 230 THE ACTINOMYCETES, Vol. I Table 63 Antibacterial activities of the various streptomycins (Rake et al.) Minima 1 inhibiting concentration,* Mg/ml Test organism Strepto- mycin Dihydro- strepto- mycin Manno- sido- strepto- mycin Dihydro- manno- sidostrep- tomycin K. 'pneumoniae (ATCC 9997) Aer. aerogenes (ATCC 129) E. coli (D 56) Sal. schottmulleri (D51) (D15) Sal. enteriditis (D 61) Sh. sonnei (H
. The actinomycetes. Actinomycetales. 230 THE ACTINOMYCETES, Vol. I Table 63 Antibacterial activities of the various streptomycins (Rake et al.) Minima 1 inhibiting concentration,* Mg/ml Test organism Strepto- mycin Dihydro- strepto- mycin Manno- sido- strepto- mycin Dihydro- manno- sidostrep- tomycin K. 'pneumoniae (ATCC 9997) Aer. aerogenes (ATCC 129) E. coli (D 56) Sal. schottmulleri (D51) (D15) Sal. enteriditis (D 61) Sh. sonnei (H 1414) Sh. clyseyiteriae (H 141) Br. abortus (Hud- dleson 1119 av- irulent) H. influenzae type b (D 68) M. pyogenes (Staphylococ- cus) var. aureus (209 P) Staph, pyogenes (C203) Mycobacterium tu- berculosis: H37Rv Ravenel BCG Nt Tt Pt ODt Kt * All figures are given in terms of weight of the trihydrochlorides. On the basis of assays with A'. pneumoniae, the streptomycin and dihydrostrep- tomycin would have an activity of 820 units per mg, the mannosidostreptomycin an activity of 236 units per mg, and the dihydromannosidostrepto- mycin 228 units per mg. t Strains of M. tubcrrulosi.'i freshly isolated from human cases. raffinose-negative, but are xjdose-, manni- tol-, and lactose-positive. The various strep- tomycin- and streptothricin - producing strains belong to this group. II. Those organisms that show the same type of carbon utilization. These include strains of S. griseus, S. olivaceus, and S. poolensis. Groups III-VI comprised mostly strep- tothricin-, chloramphenicol-, and tetra-cy- cline-forming groups. A combination of chemical, physical, and biological properties of the antibiotics pro- duced by act
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