. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 197 pale, oval frequently pyknotic, nuclei. The cytoplasm is abundant, acidophilic and often contains coarse keratohyalin granules. These cells grade over into smaller, closely packed, disorderly, polyhedral to somewhat spindle-shaped cells. They possess a relatively small amount of eosinophilic cytoplasm and contain oval, moderately hypochromatic nuclei with scattered coarse chromatin granules. Scattered foci of brown pigment resembling melanin are often seen. Mitoses
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 197 pale, oval frequently pyknotic, nuclei. The cytoplasm is abundant, acidophilic and often contains coarse keratohyalin granules. These cells grade over into smaller, closely packed, disorderly, polyhedral to somewhat spindle-shaped cells. They possess a relatively small amount of eosinophilic cytoplasm and contain oval, moderately hypochromatic nuclei with scattered coarse chromatin granules. Scattered foci of brown pigment resembling melanin are often seen. Mitoses are frequent in these smaller cells. Epithelial pearl. YiG. 105.—Epidermoid carcinoma from the lip of a female mouse. A, tumor invad- ing dermis around vibrissa (X200); B, cellular detail of this same tumor (X400). Occasionally a very malignant form shows little epithelial pearl formation (Fig. 107). It may consist of wildly growing spindle-shaped epithelial tumor cells that blend with narrow strands and small nests of the smaller types of polyhedral epithelial tumor cells (Fig. 108B). Unless the origin can be traced to the epidermis in this type of tumor, the architecture is so mis- leading that it could confuse one in interpreting the histopathology. ]\Iitoses are abundant. Carcinomas of skin appendages.—These all give the same general picture. They originate in the specialized sebaceous glands of the head region of. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Roscoe B. Jackson Memorial Laboratory; Little, Clarence C. (Clarence Cook), b. 1888; Snell, George D. (George Davis), 1903-; Dingle, John H. (John Holmes), 1908-. Philadelphia, The Blakiston company
Size: 1784px × 1400px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., boo, bookcentury1900, bookcollectionbiodiversity, booksubjectmice
