. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. 224 BIOLOGY OF THE LABORATORY MOUSE Solid tumors.—In the non-tumorous ovary the changes of the follicular cells into granulosa cells and their further differentiation to form lutein cells are not sharp but gradual. For this reason definite lines cannot be drawn, and borderline cell types can be observed. Therefore, there is justification for considering that the tumors made up of cells resembling the above phases should be grouped together. The growing tendency is to call all such tumors granulosa-c
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. 224 BIOLOGY OF THE LABORATORY MOUSE Solid tumors.—In the non-tumorous ovary the changes of the follicular cells into granulosa cells and their further differentiation to form lutein cells are not sharp but gradual. For this reason definite lines cannot be drawn, and borderline cell types can be observed. Therefore, there is justification for considering that the tumors made up of cells resembling the above phases should be grouped together. The growing tendency is to call all such tumors granulosa-ccll tumors. This type is the most common of. Fig. 122.—Papillary cyst adenoma of the ovary (X200). the solid ovarian tumors observed here. Grossly they are usually rather large. This places in one group tumors that show a wide variation in the type and arrangement of cells. The cells may be fairly uniform and rather closely resemble foUicular, granulosa, theca or lutein cells. However, there is often what appears to be a mixture of two or more of these cell types. The cells may be arranged in a pattern that resembles closely packed, large and small follicles, some distinct and some confluent, separated by thin septa of stroma. Sometimes the cells grow in irregular cords which bear a resemblance to the trabeculae seen in the early stages of corpus luteum formation. There may also be seen more or less solid masses of cells with some stroma and scattered, almost gland-like foci that resemble attempted follicle formations. There are other tumors with large, pale, spindle shaped. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Roscoe B. Jackson Memorial Laboratory; Little, Clarence C. (Clarence Cook), b. 1888; Snell, George D. (George Davis), 1903-; Dingle, John H. (John Holmes), 1908-. Philadelphia, The Blak
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