. The endocrine organs; an introduction to the study of internal secretion . FIG. 97.—Effect of addition of extract of hilum ovarii of cow to Lockes solution in which acornu of uterus of rat was suspended. Notice the cessation of rhythmic contractions anddiminution of FIG. 98.—Effect of addition of liquor folliculi of cow to Lockes solution in which a cornu of ratuterus was suspended. Notice the increase of tone with cessation of rhythmic Locke the liquor folliculi was removed and Lockes solution substituted. with marked diminution of tone. Rarely this inhibitory effect rat
. The endocrine organs; an introduction to the study of internal secretion . FIG. 97.—Effect of addition of extract of hilum ovarii of cow to Lockes solution in which acornu of uterus of rat was suspended. Notice the cessation of rhythmic contractions anddiminution of FIG. 98.—Effect of addition of liquor folliculi of cow to Lockes solution in which a cornu of ratuterus was suspended. Notice the increase of tone with cessation of rhythmic Locke the liquor folliculi was removed and Lockes solution substituted. with marked diminution of tone. Rarely this inhibitory effect rather thanincreased contraction is obtained with the other extracts. It appears probable from these observations that ovarian extracts con-tain two different kinds of autacoid acting upon plain muscle, especially upon 144 The Endocrine Organs that of the uterus. One of these is a hormone, and either excites the muscleto contraction or renders it more excitable to the natural stimuli which areproducing the contractions; the other is a chalone, tending to prevent ordiminish the contractions. The difference of result obtained would depend uterus kidney carotid respira-tions time in 10signal
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