. A practical treatise on medical diagnosis for students and physicians . here may be 4,000,000 red cells, but only 30 per cent, of haemo-globin. Sometimes there is no diminution in the number of red cells ;the latter, however, appear pale (achromia), vary considerably in size,microcytes and occasionally poikilocytes are present, and, in severe cases,nucleated red corpuscles are found; occasionally macrocytes occur, but ingeneral the size of the red cells is below that which is usually number of leucocytes varies but little from the normal, but theremay be a slight increase. Occasion


. A practical treatise on medical diagnosis for students and physicians . here may be 4,000,000 red cells, but only 30 per cent, of haemo-globin. Sometimes there is no diminution in the number of red cells ;the latter, however, appear pale (achromia), vary considerably in size,microcytes and occasionally poikilocytes are present, and, in severe cases,nucleated red corpuscles are found; occasionally macrocytes occur, but ingeneral the size of the red cells is below that which is usually number of leucocytes varies but little from the normal, but theremay be a slight increase. Occasionally there is a rise of temperature, butit is probably due to some complication. (See Plate XVIII.—B, Fig. 1.) The cause of chlorosis has not been determined satisfactorily. Vir-chow has established the existence of congenital narrowing of the blood-vessels. Sir Andrew Clark thinks it is due to the absorption of poisonousmatter from the intestines ; the great benefit that follows saline purgativesin many cases indicates that fecal toxaemia is a factor in these Pernicious Ansemia. 1. Large Mononuclear I,ymphocyte. 5. Small Lymphocyte. 2. Polymorphonuclear Leucocyte or Neutrophile. 6. Poikilocyte. 3. Megaloblast )»,,,,„,„ . 7. Normal Red ,• 1., ^ f Nucleated Red Corpuscles. 4. Microblast > / PERNICIOUS ANEMIA. 837 Forchlieimer ^ also looks upon it as intestinal in origin. Sex and pubertyare predisposing eauses-; but chlorosis may occur in boys, and appear ingirls before puberty, and in young wonien considerably alter that period. Fig. 332. Blood-charts comparing pernicious ana?mia and chlorosis. DATE X >^ 1/ /l9 X 1/ 2/ 2/ 2/ 3//I X X 3/^/25 / no; A 105 / N y*^ V 100 5,000,000 J / s V / ^^s^ 95 y \, / 90 1 / V 85 y / ,..•* 80 4,000,000 ^ / ,.•• t / 75 ^.»_ _ ^ •• • y 70 1 • . o ■••■• --V 65 a / A- 60 3,000,000 < / \ 1 55 • i 1 \ y« 50 ] • v. 45 ^* K ** / • \ 40 2,000,000 / • v- I f *1 N /\ 35 f • J • V \


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