AMAarchives of neurology & psychiatry . , and Schnabel, A.: Das Xirus des Herpes febrilis and seineReziehungen zum Virus der Encephalitis epidemica (lethargica), Schweiz. 51:469 (May 19) 1921. Weitere experimentelle Beitrage zurAetiologie und Verbreitungsart des Herpes febrilis beim Menschen. ibid. p. 562. 17. Blanc, G., and Caminopetros. J.: Recherches experimentales sur Iherpes,Compt. rend. Soc. de biol. 84:629-630. 767-770, 859-860. 1921. 18. Luger, A., and Lauda. E.: Zur Aetiologie des Herpes Febrilis, d. ges. exper. Med. 24:19. 1921. THALHIMER—EPIDEMIC E\ CEPHA
AMAarchives of neurology & psychiatry . , and Schnabel, A.: Das Xirus des Herpes febrilis and seineReziehungen zum Virus der Encephalitis epidemica (lethargica), Schweiz. 51:469 (May 19) 1921. Weitere experimentelle Beitrage zurAetiologie und Verbreitungsart des Herpes febrilis beim Menschen. ibid. p. 562. 17. Blanc, G., and Caminopetros. J.: Recherches experimentales sur Iherpes,Compt. rend. Soc. de biol. 84:629-630. 767-770, 859-860. 1921. 18. Luger, A., and Lauda. E.: Zur Aetiologie des Herpes Febrilis, d. ges. exper. Med. 24:19. 1921. THALHIMER—EPIDEMIC E\ CEPHALITIS 291 a filtrable virus in the fluid of the vesicles of herpes fel)rilis which on injectionproduced herpes in the cornea of animals. This condition can be transmittedindefinitely from animal to animal. MATERIAL AND METHODS The experimental and cultural methods used throughout this investi-gation were the same as those described in the preliminary communica-tion ^ and identical with those previously described by Loewe Fig. 4.—Brain of a rabbit inoculated intracranially with virus which hadbeen passed through another rabbit. The material and experiments are collected in the table. Animalinoculations referred to as positive are those in which microscopic brainlesions were foimd. identical with those present in fatal human inoculations were made intracranially. Positive cultures in the tissue-ascites medium, perfected by Noguchi, of aminute filtrable organism having the same morphologic, cultural andbiologic characteristics as those recovered by Loewe and The cases which came to necropsy ran typical clinical courses andvaried from a fulminating case, with death eighteen hours after thefirst symptoms, to one of lethargic type which lasted eighteen monthswith remissions and relapses. 292 AKCnniiS OF SEUROLOGY AND ISYCIIIATKY Tlie brains in all these cases showed characteristic lesions ; that is,perivascular round cell infiltr
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