Morgan's sex linkage experiment, illustration. Punnet square showing one of the experiments performed in 1910 by US geneticist Thomas Hunt Morgan. He
Morgan's sex linkage experiment, illustration. Punnet square showing one of the experiments performed in 1910 by US geneticist Thomas Hunt Morgan. He crossed a mutant white-eyed male fly (Drosophila melanogaster) with a red-eyed female fly to produce a generation of F1 flies. He then mated a white-eyed male (upper left) with an F1 red-eyed female fly (upper right) to obtain the F2 generation illustrated here. The X chromosome is carrying the colour trait: white (W) or red (R). The F2 males have white eyes when they inherit the mutant (white) gene on the X chromosome from their mother. F2 females only show the trait if they inherit mutant genes on both X chromosomes. This phenomenon is known as sex link inheritance, and the trait examined here is an X-linked recessive trait. This work led to Morgan being awarded the 1933 Nobel Prize in Physiology or Medicine.
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Photo credit: © CARLOS CLARIVAN/SCIENCE PHOTO LIBRARY / Alamy / Afripics
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