. The Journal of nervous and mental disease. al lymph spaces. The infiltrative cells consistfor the most part of small lymphocytes. These vascular changesare most marked in the vessels entering the lateral and antero-lat-eral surfaces of the medulla. With the fat stains, in all the vesselsobserved, one may note a considerable increase in all the adventitialcells. In the cytoplasm of these cells large numbers of small andmedium-sized fat granules are to be seen so that the vessel wall ap-pears infiltrated with fat. However, all of the fat is surrounding many of these v


. The Journal of nervous and mental disease. al lymph spaces. The infiltrative cells consistfor the most part of small lymphocytes. These vascular changesare most marked in the vessels entering the lateral and antero-lat-eral surfaces of the medulla. With the fat stains, in all the vesselsobserved, one may note a considerable increase in all the adventitialcells. In the cytoplasm of these cells large numbers of small andmedium-sized fat granules are to be seen so that the vessel wall ap-pears infiltrated with fat. However, all of the fat is surrounding many of these vessels rather large fatgranular glia cells appear, most of them lying in the adventitiallymph space. But in every instance there are a few to be seen inthe nerve tissue, somewhat removed from the blood vessels. There PATHOLOGY OF POLIOMYELITIS 5 are no hemorrhages free in the tissues and no scattered invasion ofnerve tissue by obvious lymphocytic elements such as are observedm the cord. Of the ectodermal tissue, the nerve cells of the hypo-. FiG. 8. Section of medulla. Human case Xo. 501, X 300, showing fat-ladencells in adventitial space of a blood vessel. g-lossal nucleus and nucleus ambiguus as well as the smaller cellsof the reticular formation and those of the olivary nucleus appearnormal in shape and in histological structure. The neuroglia cellsare mcreased in number and fat granular, glia cells are to be seen ii6 HUBERT S. HOIVE in considerable numbers. In the reticular formation and otherareas where white and gray are intimately mixed this last conditionis not generally widespread, but it is seen best in isolated areas ofirregular size, which seem to bear no particular relation to the blood-vascular supply or to the large masses of gray matter. The whitefibers everywhere appear normal. Pons.—In the pons very little pathological change is to be the blood vessels there is little if any vascular infiltration. Hereand there adventitial cells are seen which contai


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