AMAarchives of neurology & psychiatry . Orig. 57:122-173, 1920. Klinik und Pathogeneseder Paralyse im Lichte der Spirochatenforschung, ibid., Orig. 70:254-299, 1921. 4. Jahnels method is described by Stevenson, George S.: Two RecentImprovements in the Staining of Spirochetes in X^^ervous Tissue, Arch. Psychiat. 7:349 (March) 1922. 590 AKCIIiriiS OF MiUkOLOc;) AM) ISVCIllATKV ( Xalcnlc. 70 per S])ir()cliees are believed t(» be ]>resent in allcases of general ])aral\sis. and the longer one hunts and the greaterthe number of areas studied, the smaller is the percentage o
AMAarchives of neurology & psychiatry . Orig. 57:122-173, 1920. Klinik und Pathogeneseder Paralyse im Lichte der Spirochatenforschung, ibid., Orig. 70:254-299, 1921. 4. Jahnels method is described by Stevenson, George S.: Two RecentImprovements in the Staining of Spirochetes in X^^ervous Tissue, Arch. Psychiat. 7:349 (March) 1922. 590 AKCIIiriiS OF MiUkOLOc;) AM) ISVCIllATKV ( Xalcnlc. 70 per S])ir()cliees are believed t(» be ]>resent in allcases of general ])aral\sis. and the longer one hunts and the greaterthe number of areas studied, the smaller is the percentage of failure tofind them. Spirocheles may be found in any region of the brain, but all of theauthors agree that the frontal lobes, especially the anterior |)arts ofthese where the changes in the tissues are greatest, offer the best oppor-tunities for finding them. They are seldom seen in the pia mater;seldom in the outer layer of the cortex; almost never in the whitematter. .As a rule, tlicy are most abundant in the middle and deeper. Fig. 1.—Photomicrograph of in tliUu^c distriliution ; 4 mm. Zeissobjective, ocular Xo. 6. This field is from a part of a section in whichspirochetes were alnmdanl; in many other parts of this section none were found. This illustration and Figure 2 show spirochetes from the left frontal regionof a patient with general paralysis, C. D., of the Institute collection; receivedfrom Willard State Hospital in 1911. The brain when received showed evi-dence of partial decomposition: it had been kept in 10 per cent, liquor for-maldehydi for about ten years before the sections were removed. They werestained by Dr. G. S. Stevenson by Jahnels method. lavers of the gray matter, a point of great practical importance insearching for them. They are rather more likely to be found in thegray matter along the fissures than at the tops of the convolutions and DUXLAP—GEXERAL PARALYSIS 591 may (rarely) when stained be so numerous as to cause dark spotsvisib
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