Clinical and pathological papers .. . Chromatin would seem to be, then, an unstainable material de-rived from the cytoplasm plus nucleolar substance. The latteris the material by which, on the one hand, the nucleus derives from Digitized by Microsoft® William Travis Howard and Oscar T. Schultz. 19 the cytoplasm the substances necessary to the former and by meansof which, on the other hand, the nucleus controls the varying activ-ities of the cell. The nucleolar substance, therefore, is of primeimportance in the interdependence which exists between nucleusand cytoplasm and is necessary for the m
Clinical and pathological papers .. . Chromatin would seem to be, then, an unstainable material de-rived from the cytoplasm plus nucleolar substance. The latteris the material by which, on the one hand, the nucleus derives from Digitized by Microsoft® William Travis Howard and Oscar T. Schultz. 19 the cytoplasm the substances necessary to the former and by meansof which, on the other hand, the nucleus controls the varying activ-ities of the cell. The nucleolar substance, therefore, is of primeimportance in the interdependence which exists between nucleusand cytoplasm and is necessary for the maintenance of a propernucleus-plasma relation. Hertwigs idea concerning the nucleolar substance may be ex-pressed diagramatically, and the same means may be used for ampli-fying this idea and for making clear certain of the events whichoccur in the regulatory phenomena necessary for maintaining theproper balance between the nucleus and plasma. In the diagramsthe chromatin is represented by black, and nucleolar substance Text-figure i. Text-figure 2. The participitation of the nucleolar substance in the formation ofchromatin is illustrated by Text-figure 1, the passage of materialsinto the nucleus, where they become visualized as chromatin, beingindicated in this and in Text-figures 2, 3, 4, 5, and 6 by the arrow(a). If there is no excess of nucleolar substance stored in a mor-phologically differentiated intranuclear body, this process results inthe formation of a nucleus with chromatin more or less chromatin visualization is only one side of the nucleus-plasma Digitized by Microsoft® 20 Studies in the Biology of Tumor Cells. equation. In Text-figure 2 is shown a further stage, the passageof chromatin derivatives into the cytoplasm, there to be used in theactivities of the cell. This step is designated by the arrow (c).If the nucleus contains a nucleolus, chromatin may be deposited hereand then passed on in order to become diffused throughout the nu-c
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectclinica, bookyear1901
